lncRNAs are involved in various diseases (cancer, ageing, neurodegeneration, and cardiovascular disease) and signalling pathways (p53, NF-κB, PI3K/AKT and Notch) and play an important role in tumour proliferation, migration, and invasion as tumour-promoting molecules or tumour-inhibiting molecules [36–38]. This evidence concerns the gene TP53 and cardiovascular disorder.