In our previous study, we have found secoemestrin C, an epipolythiodioxopiperazine compound, displayed significant cytotoxicity against several pancreatic adenocarcinoma cells, and enhanced the endoplasmic reticulum stress by a unique mechanism with downregulation of the YAP via the destruction complex (YAP-Axin-GSK-βTrCP) (Wang et al., 2022). The gene discussed is BTRC; the disease is pancreatic adenocarcinoma.