Moreover, high expression of cholesterol synthesis enzyme 3β-hydroxysteroid-Δ24 reductase (DHCR24) has been found in human HCC liver, whereas inhibiting DHCR24 impeded tumor growth, invasion, and metastasis both in liver cancer cell lines and in Hep3B xenografts (Wu et al., 2020). Here, DHCR24 is linked to hepatocellular carcinoma.