That being said, it has been shown in NASH-linked HCC that immunosurveillance is impaired, the proportion of monocyte-derived macrophage versus KCs is increased, cancer promoting inflammation is enhanced, and T cells capable of eliminating the tumor are dysfunctional (Ringelhan et al., 2018; Hou et al., 2020; Li et al., 2021; Barreby et al., 2022). Here, TBCE is linked to metabolic dysfunction-associated steatohepatitis.