This may be critical for HCC progression as downregulation of TXNIP and its impact on glucose metabolism has been recognized as a hallmark in prostate, lung, and colorectal cancer (Qu et al., 2018; Tang et al., 2020; Hu et al., 2021), and TXNIP downregulation was evident in HBV-related HCCs and contributed to cancer initiation (Zhang et al., 2021). Here, TXNIP is linked to colorectal cancer.