Mice with liver-specific or whole body deletion of NFκB essential modulator (NEMO), peroxisome proliferator activated receptor alpha (PPARα), farnesoid x-activated receptor (FXR), acetyl CoA oxidase (ACOX1) and methionine adenosyltransferase 1A (MAT1A) have also been used as models of NASH driven HCC, but poorly resemble clinically presented NASH (Nakagawa, 2015; Febbraio et al., 2019; Mohs et al., 2021). Here, NR1H4 is linked to hepatocellular carcinoma.