CASP3 and cataract: Basu et al. (2012) described development of chick lens fibres as a process of differentiation, where low levels of caspase-3 activation is regulated by IGF-1R/NFκB signalling and caspase-3-deficient mice exhibited cataracts (Zandy et al., 2005). However, further investigation showed that neither caspase-3 nor other executors are required for the elimination of organelles from lens fibres (Zandy et al., 2005).