In breast cancer (Gong et al., 2020) and colorectal cancer (Zhu et al., 2019), ZC3H13 plays a tumor suppressive role, while in hepatocellular carcinoma, ZC3H13 promotes the malignant behavior of hepatocellular carcinoma cells (Wang Q. et al., 2021). The gene discussed is ZC3H13; the disease is breast carcinoma.