In breast cancer (Gong et al., 2020) and colorectal cancer (Zhu et al., 2019), ZC3H13 plays a tumor suppressive role, while in hepatocellular carcinoma, ZC3H13 promotes the malignant behavior of hepatocellular carcinoma cells (Wang Q. et al., 2021). Here, ZC3H13 is linked to colorectal cancer.