On the other hand, after a while, the IL-1 chronic production will reprogram the senescence tumors to re-enter the cell cycle, in a condition known as “post-senescence” acquiring stemness properties and promoting tumor relapse (Gelfo et al., 2016; 2018; 2020; Milanovic et al., 2017; Lee and Schmitt, 2019; Saleh et al., 2019; Romaniello et al., 2020; Jochems et al., 2021). Here, IL1A is linked to neoplasm.