EGFR and breast cancer: For instance, high levels of the pro-inflammatory cytokines IL-1, IL-6, and IL-8 are among the main soluble factors found in the SASP, responsible for increasing the invasiveness of a panel of breast cancer cell lines (Coppé et al., 2008); or for impairing the response to EGFR neutralization by monoclonal antibody (Gelfo et al., 2016; 2018; 2020) and kinase inhibitors (Stanam et al., 2016).