Studies have shown that in atopic dermatitis, mast cells are recruited by chemokines and activated by IgE and non-IgE factors to produce a series of inflammatory factors [17]; interact with nerve cells, T cells, eosinophils, keratinocytes, etc.; and jointly participate in the process of skin itching and inflammation in atopic dermatitis [16, 18]. The gene discussed is IGHE; the disease is atopic eczema.