The deletion of the 13q14.3 region spans several TSGs, including FAM10A4 (Sossey-Alaoui et al., 2002), DLEU7 (Palamarchuk et al., 2010), KCNRG (Birerdinc et al., 2010), and RB1 (Liu et al., 1993), which have been reported to be related to CLL aetiology. The gene discussed is RB1; the disease is B-cell chronic lymphocytic leukemia.