Nine low expressed DMEGs were selected with hypermethylated in promoter and hypomethylated in body, such as ADAMTS17, and 83 high expressed DMEGs were selected with both hypomethylated in promoter and body, such as ZAP70, FMOD, PAX9. 48 CLL cases were characterized into three subgroups based on SVM model. The gene discussed is ADAMTS17; the disease is B-cell chronic lymphocytic leukemia.