There were nine DMEGs by combining 326 DMEGs and 226 DMEGs, including MACROD2, ADAMTS17, TJP1, MET, OSBPL1A, SYN2, KCNG2, AGBL4, and ME3, were lower expressed in CLL cases with hypermethylated DMPs in promoter regions and hypomethylated DMP in body regions (Supplementary Table S8E). The gene discussed is MACROD2; the disease is B-cell chronic lymphocytic leukemia.