Univariate Cox regression analysis showed that the expression of HK3 was associated with poor OS in GBM, kidney renal clear cell carcinoma (KIRC), brain lower grade glioma (LGG), thymoma (THYM), uveal melanoma (UVM), kidney chromophobe (KICH), acute myeloid leukemia (LAML), testicular germ cell tumors (TGCT), and liver hepatocellular carcinoma (LIHC), but associated with favorable OS in skin cutaneous melanoma (SKCM) (Figure 2A). This evidence concerns the gene HK3 and testicular germ cell tumor.