CGA and neuroendocrine neoplasm: CHGA, known as Chromogranin A (CgA), a protein stored in the secretory granules of many neuroendocrine cells and neurons, could be detected in the blood of patients with neuroendocrine tumors or heart failure (Seregni et al., 2001; Ferrero et al., 2004) CHGA could also be detected in the serum of some HCC patients (Leone et al., 2002).