Meanwhile most of the immune checkpoints in high-risk patients with HCC were upregulated, including CD8 (+) T-cell immune checkpoints (PD-1, CTLA-4, and TIGIT) and NK cell immune checkpoints (PD-1, LAG-3, and TIM-3) (Zhou et al., 2019). The gene discussed is CTLA4; the disease is hepatocellular carcinoma.