IFNG and neoplasm: IFN-γ also plays an important role in regulating immune response; antigen presentation (Ivashkiv, 2018); inflammation; chemotactic signaling (Mauldin et al., 2016); modulating extracellular matrix, thereby affecting metastasis and tumor structure (Glasner et al., 2018); and activation and polarization of white blood cells (Burke and Young, 2019).