AKT1 and neoplasm: Moreover, ssGSEA results revealed that tumor-related pathways (for example, epithelial-mesenchymal transition, TGF-β signaling, angiogenesis, Wnt-β signaling, Notch signaling and PI3K-Akt signaling, P53 signaling, hypoxia) and immune-related pathways (for example, IL6-JAK-STAT3 signaling, complement, inflammatory response, interferon response) showed a significantly higher enrichment score in C1 (p < 0.001, Figures 2B, C).