TP53 and brain ischemia: Similarly, in the model of simulating cerebral ischemia, mouse focal cerebral ischemia, global cerebral ischemia (GCI) and transient frontal-temporal ischemia, it is found that the mRNA and protein of P53 in the ischemic area are elevated (van Lookeren Campagne and Gill, 1998; Watanabe et al., 1999; Hong et al., 2010).