MAPT and Alzheimer disease: The main pathological characteristics of AD are diffuse atrophy of the cerebral cortex and massive synaptic loss and excessive phosphorylated tau protein aggregates in cells (Qi et al., 2019), which is considered to be associated with many neurodegenerative diseases, and changes in tau protein are believed to be the result of downstream Αβ protein toxicity in the amylosis hypothesis (Dickson et al., 2013).