TP53 and brain infarction: In three groups of mice experiments: P53 KO mice (P53−/−), heterozygous (P53+/−) mice, and WT mice (P53+/+), the results showed that both P53 KO and heterozygous groups had an improved neurological function and reduced area of cerebral infarction, and P53 KO group showed a better protective effect (Havel et al., 2015).