Among ten hub genes, the high expression of LGALS1 and TIMP1 were correlated significantly with the poor OS, and the high expression of LGALS1, TIMP1, C3, CHGB, GPC3, P4HB, and VCAN were correlated with the low DFS of ccRCC significantly. This evidence concerns the gene CHGB and nonpapillary renal cell carcinoma.