Based on the MCC scores of the CytoHubba plugin in Cytoscape, the top 10 hub genes correlated with ccRCC were picked out, including, KNG1, TIMP1, ALB, C3, GPC3, VCAN, P4HB, CHGB, LGALS1, and EGF. The gene discussed is P4HB; the disease is nonpapillary renal cell carcinoma.