With the development of bioinformatics, although some biomarkers related to ccRCC have been found in recent years, such as AOX1 (Xiong et al., 2021), circCHST15 (Gui et al., 2021), DDX39 (Bao et al., 2021) and PPAR α (Luo et al., 2019), the risk of death in patients with ccRCC is still high, so it is necessary to find more reliable markers and obtain more treatments to reduce the risk of death in patients with ccRCC. This evidence concerns the gene DDX39A and nonpapillary renal cell carcinoma.