Based on the MCC scores of the CytoHubba plugin in Cytoscape, the top 10 hub genes correlated with ccRCC were picked out, including, KNG1, TIMP1, ALB, C3, GPC3, VCAN, P4HB, CHGB, LGALS1, and EGF. This evidence concerns the gene EGF and nonpapillary renal cell carcinoma.