Among ten hub genes, the high expression of LGALS1 and TIMP1 were correlated significantly with the poor OS, and the high expression of LGALS1, TIMP1, C3, CHGB, GPC3, P4HB, and VCAN were correlated with the low DFS of ccRCC significantly. Here, LGALS1 is linked to nonpapillary renal cell carcinoma.