Among ten hub genes, the high expression of LGALS1 and TIMP1 were correlated significantly with the poor OS, and the high expression of LGALS1, TIMP1, C3, CHGB, GPC3, P4HB, and VCAN were correlated with the low DFS of ccRCC significantly. The gene discussed is P4HB; the disease is nonpapillary renal cell carcinoma.