In general, ADC is diagnosed with morphological findings of acinar/tubular structures or mucin production as well as IHC-positive markers for TTF-1 and/or Napsin-A and SCC is defined by keratinization or intercellular bridges with associated IHC markers such as P-40, P-63, and CK-5/CK-6, with P-40 being the most sensitive and specific. This evidence concerns the gene KRT5 and AIDS dementia complex.