In keyword burst detection, “systematic pharmacology” and “drug discovery” have highest intensity, “amyloid precursor protein” had longest sustained burst, and the latest bursts were concentrated in “systematic pharmacology,” “database,” “traditional Chinese medicine,” and “alzheimers disease” suggested that the current hotspots may be focused on the exploration of therapeutic methods for AD. This evidence concerns the gene APP and early-onset autosomal dominant Alzheimer disease.