Su’s group demonstrated that Tan IIA-induced recruitment of the sestrin 2 (SESN2) promoter through the hematopoietic progenitor kinase-germinal cell kinase-like kinase/stress-activated protein kinase/c-Jun N-terminal kinase (HGK/SAPK/JNK-Jun) signaling axis led to SESN2/AMPK-α activation, thereby inducing autophagy and inhibiting osteosarcoma growth (Yen et al., 2018). This evidence concerns the gene SESN2 and osteosarcoma.