HK2 and Cowden syndrome 1: Owing to the infiltration of CD8+ T cells being significantly decreased in CS group, among the 16 genes, CA12, EGFR, FABP4, FABP5, HK2, MAGEA3, MAGEA6, SEC61G, SLC2A1, SLC5A1, and TMEM45A were significantly negatively correlated with CD8+ T cells infiltration (Supplementary Figure S2), while the most significant negative correlation existed in SEC61G (partial correlation: −.273, p = 1.52e-09), also known as endoplasmic reticulum (ER) SEC61 gamma subunit.