Specifically, miR-887-3p might accelerate renal dysfunction via PI3K/Akt, which in turn leads to the inactivation of the transcription factor FoxO3a and the subsequent downregulation of its proapoptotic genes, consequently inducing TGF-β-mediated mesangial cell survival and oxidative stress in the early DN (Kato et al., 2006). The gene discussed is TGFB1; the disease is liver dysplastic nodule.