TGFB1 and renal fibrosis: The involvement of miR-192 in the development of DN has been previously reported in both in vitro and in vivo studies showing that its inhibition can result in a significant increase of its target Zinc Finger E-Box Binding Homeobox 1/2 (ZEB1/2), which in turn reduced the expression of collagen, TGF-β and fibronectin, known mediators of renal fibrosis (Putta et al., 2012).