ACOX1 and liver dysplastic nodule: Extensive accumulation of lipid droplets in TECs, podocytes, mesangial cells and fenestrated endothelial cells is observed in DN patients (Herman-Edelstein et al., 2014), accompanied by downregulation of acyl-CoA oxidase 1 (ACOX1), carnitine palmitoyltransferase 1 (CPT1), and peroxisome proliferator-activated receptors (PPAR-α and -β), and upregulation of LDL receptor and fatty acid transporter CD36 (Herman-Edelstein et al., 2014).