According to previous studies, and the increase of Discs large homolog 3 (DLG3) gene can activate the Hippo signaling pathway (Chen et al., 2020a) and has the effect of suppressing further deterioration of GC (Li et al., 2020), oral squamous cell carcinoma, breast cancer (Liu et al., 2019), colon cancer and lung cancer. The gene discussed is DLG3; the disease is oral cavity squamous cell carcinoma.