Furthermore, our study elucidated that Forsythiaside exerted potential treatment against DKD which may act directly RHOA and PRKCA target by suppressing the oxidative stress pathway in podocytes, which preliminarily reflected the characteristics of multi-target and multi-action pathway of Forsythiaside in treating DKD from the point of view of cellular precision therapy. This evidence concerns the gene PRKCA and diabetic kidney disease.