At the same time, histone three acetylation and ERK1/2 phosphorylation of AML1-ETO–positive AML cells were inhibited, and the ERK1/2 pathway was regulated to inhibit the proliferation of AML1-ETO–positive AML cells and c-kit expression was reduced (Liu et al., 2020). The gene discussed is RUNX1; the disease is acute myeloid leukemia.