To evaluate whether HMGB1 levels constitute a risk factor independent of early AKI prediction in HBV-ACLF patients, as confounding covariates, we included age, ascites, CysC, sCr, and CLIF-C ACLF scores and performed 1:1 propensity score matching (n = 138, 69 patients with AKI were matched to 69 patients without AKI). This evidence concerns the gene HMGB1 and acute kidney injury.