Mutations in the SynGAP1 gene have been linked to stroke (Zhang et al., 2020; Yang et al., 2022) and neurodevelopmental disorders, such as cognitive dysfunction (Lai et al., 2021; Kilinc et al., 2022), autism spectrum disorders (Harris et al., 2021), schizophrenia (Gamache et al., 2020) and epilepsy (Creson et al., 2019). Here, SYNGAP1 is linked to autism spectrum disorder.