The final model developed to estimate the individual predicted risk of 30-day frailty was presented as a regression formula: predicted risk of 30-day frailty = [1/(1+e−riskscore)], where riskscore = −0.106 + 0.034 × age + 0.796 × sex −0.361 × vision dysfunction + 0.373 × hearing dysfunction + 0.408 × urination dysfunction – 0.012 × ADL + 0.064 × depression – 0.139 × nutritional status – 0.007 × hemoglobin – 0.034 × serum albumin – 0.012 × (male: ADL). The gene discussed is ALB; the disease is major depressive disorder.