In this study, rat models with dextran sodium sulfate (DSS)-induced enteritis were used to explore the effect and mechanisms of oat AMPs on IBD through pathological analysis, hematoxylin and eosin (H&E) staining, assessment of antioxidant indicators, and the comparative analysis of microorganisms and their metabolites in the colon of rats in different experimental groups. Here, ADSL is linked to enteritis.