CCNE1 and breast cancer: Breast Cancer: curcumin down regulate of NF-jB, AP-1, COX-1, and –2, VEGF, fibroblast growth factor (FGF), cyclin E, IL-6, and –11, TGF-b, MMP-2, MMP-9, and MMP-13, the upregulation of tissue inhibitor of metalloproteinase-1.