STAT3 and cancer: Ovarian Cancer: curcumin prevents NF-jB and STAT3 activation and inactivate propagation of human ovarian cancer cell lines SKOV3ip1, HeyA8, and HeyA8-MDR, prevent ovarian cancers in athymic mice. In the SKOV3ip1 and HeyA8 in vivo models, curcumin lowered micro-vessel density and angiogenesis, and elevated cancer cell apoptosis.