Colorectal Cancer; curcumin therapy reveals cell shrinkage, chromatin condensation and DNA fragmentation by increasing growth arrest via pro-motion of the DNA damage-inducible gene (DDIT3) at the protein and mRNA levels in colon cancer cell lines, prevents the propagation of colon tumor cell lines and stimulates apoptosis by caspase-3-mediated b-catenin cleavage, downregulate c-Myc, blocks cell cycle progression by cyclin D and cyclin B expression, and elevated the activity of cell division control 2. Here, DDIT3 is linked to malignant colon neoplasm.