Endothelial Per-Arnt-Sim (PAS) domain protein 1 (EPAS1) activation promotes ferroptosis by upregulating hypoxia inducible lipid droplet associated (HILPDA) expression in renal cell cancer (RCC)-derived cells, thereby increasing PUFA generation and lipid peroxidation (7). Here, EPAS1 is linked to renal cell adenocarcinoma.