Moreover, p53 can also inhibit NADPH oxidases (NOX)-mediated lipid peroxidation in colon cancer by directly binding to the dipeptidyl peptidase Dipeptidyl peptidase-4 (DPP4) or limit ferroptosis by inducing cyclin-dependent kinase inhibitor 1A (CDKN1A) expression in fibrosarcoma cells (71). Here, DPP4 is linked to malignant colon neoplasm.