The process of ferroptosis in tumors and the biological response induced by microwave ablation shared the same molecules, such as ROS, protein 53 (p53), heat shock protein (HSP), hypoxia-inducible factor (HIF), and nuclear factor erythroid 2-related factor 2 (NRF2), therefore, we consider that microwave ablation may regulate ferroptosis of tumor cells. The gene discussed is HSP90B2P; the disease is neoplasm.