Upon sustained infection, MAVS can be targeted for proteolysisleading to its degradation, loss of MAVS clusters from mitochondrialsurface, and release to the cytosol.30,31 ConcerningSARS-CoV-2 infection, several reports have shown a direct interactionwith MAVS with consequent impairment of the innate immune responsepathways. Here, MAVS is linked to COVID-19.