The association between the ERCC1 rs3212986 polymorphism and ischemic stroke susceptibility was found in both recessive (OR = 2.638, 95% CI = 1.744–3.989, P < 0.001) and additive (OR = 1.309, 95% CI = 1.028–1.667, P = 0.031) models, respectively. This evidence concerns the gene ERCC1 and ischemic stroke.