ERCC1 and brain neoplasm: Chen et al. conducted the first study to report a significant association of the rs3212986 polymorphism in ERCC1 with the risk of brain tumors and considered that the A/C rs3212986 polymorphism, which may affect mRNA stability for ERCC1, also results in an amino acid substitution of lysine to glutamine in nucleolar protein (ASE-1) and T-cell receptor complex subunit CD3 epsilon-associated signal transducer (CAST) (21).