ERCC1 and cancer: Recently, several common and putatively functional single nucleotide polymorphisms (SNPs) of ERCC1 have been identified, of which ERCC1 C118T (rs11615) at exon 4 without amino acid change and ERCC1 C8092A (rs3212986) located at the 3'-untranslated region (3'-UTR) were likely to have some effects on ERCC1 mRNA expression, which played an important role in cancer susceptibility, clinical phenotype diversity, and therapy (16–18).