Furthermore, we compared the CERES scores of UBA1 to the expression level of c-MYC across different BC models, which revealed a strong negative correlation (Fig. 1B and Supplementary Material Fig. S1A) and found UBA1 targeting was in general more toxic in c-MYC high cells, which clustered in the basal-like molecular subset, where most TNBC derive from(15). Here, UBA1 is linked to breast cancer.