Our finding that the expression of c-MYC was important in determining TAK-243 sensitivity is consistent with a recent TAK-243 study in the hematological cancer diffuse large B-cell lymphoma (DLBCL) (44), and conceptually with our recent report with n-MYC (28), where we demonstrated n-MYC sensitizes to NOXA-mediated death in neuroblastoma. This evidence concerns the gene PMAIP1 and hematopoietic and lymphoid cell neoplasm.