Participants with the highest group of Sodium (mmol/L) groups (Sodium (mmol/L) groups≥145) had higher values in SBP, respiratory rate, Temperature, Hematocrit, Platelet, Bun, WBC, RDW, SOFA, SAPS II, EVCI, and the lower values in DBP, SPO2, Albumin, Bicarbonate Potassium, and Ptt; this group consisted of more patients with Pulmonary circulation, Cardiac arrhythmias, Chronic pulmonary, Valvular disease in contrast with those in the other groups. The gene discussed is ALB; the disease is chronic obstructive pulmonary disease.