For example, circANRIL, a circRNA located at 9p21, a locus known to be involved in atherosclerosis, can bind to pescadillo homolog 1 (PES1) and restrain 60S-preribosomal assembly in VSMCs and macrophages, which lead to cell apoptosis and atherosclerosis aggravation (14). This evidence concerns the gene PES1 and atherosclerosis.