Cataracts in the eye lens are associated with mutations in Cx46, while mutations in the GJA1 gene which encodes Cx43 lead to a rare autosomal syndrome called oculodentodigital dysplasia (ODD) in which patients display diverse phenotypes such as bone malformations, vision loss, and hypotrichosis (49, 50). Here, GJA1 is linked to Oppositional defiant disorder.