GJA1 and oculodentodigital dysplasia: Cataracts in the eye lens are associated with mutations in Cx46, while mutations in the GJA1 gene which encodes Cx43 lead to a rare autosomal syndrome called oculodentodigital dysplasia (ODD) in which patients display diverse phenotypes such as bone malformations, vision loss, and hypotrichosis (49, 50).