In addition, the cardiomyogenic factor Follistatin Like 1 (FSTL1), produced by the epicardium, can stimulate recovery of contractile function within 2 weeks and limit fibrosis 4 weeks after MI injury, suggesting that FSTL1 has therapeutic efficacy in a large animal MI I/R swine model (46). This evidence concerns the gene FSTL1 and myocardial infarction.