TREM2 and early-onset autosomal dominant Alzheimer disease: As another example, the relative degradation rate of the gene coding for the triggering receptor expressed on myeloid cells-2 (TREM2), variants of which are strongly associated with increased risk of Alzheimer’s disease [24], was found to be greater in the neuronal L5 IT subclass than in other subclasses (Figure 2i, bottom row).