Of note, the IDH-mut oligodendrogliomas, astrocytoma and pediatric high-grade gliomas have the highest mutational burden and number of gene fusions across all brain diseases (Fig. 7b-c, Supplementary Fig. 7a-b) in comparison to copy number profiles (Fig. 7d-e) which show a mixture of genes with amplified and lost copy number profiles across all brain diseases. Here, IDH1 is linked to central nervous system cancer.