Adult IDH-wt glioblastoma frequently harbored gene fusions involving EGFR (17.7% of tumors, most commonly EGFR – PSPHP1, EGFR – LINC01445, EGFR – SEC61G – DT), whereas pediatric lower-grade gliomas frequently harbored BRAF fusions (KIAA1549 – BRAF in 32% of low-grade gliomas and in 60% of pilocytic astrocytomas). Here, IDH1 is linked to central nervous system cancer.