Armed with additional genomic information such as gene fusions, copy number variation and somatic alternation, we investigated members of the Reactome mismatch repair pathway (R-HAS-5358508) (Supplementary Fig. 8a-c). We observe that different genes belonging to this pathway exhibit different trends, for example genes such as POLD1(chr19), RPA2(chr1), and LIG1(chr19) loose a copy in IDH-mut oligodendrogliomas, while genes RPA3(chr19), PMS2(chr19), PCNA(chr20) and POLD2(chr7) gain a copy in IDH-wt GBM. This evidence concerns the gene LIG1 and glioblastoma.