Selecting for common glioma mutations and copy number alterations clearly shows three distinct subtypes of glioma - IDHmut-1p19q co-deleted oligodendrogliomas, the IDH mutated astrocytomas with p53 and ATRX mutations, and the wild-type IDH (IDH-wt) glioblastomas with gain of chromosome 7 and loss of chromosome 10 molecular GBM. This evidence concerns the gene ATRX and central nervous system cancer.