Interestingly, we noted that the two small clusters (IDH mutated grade 2 and grade3 oligodendroglioma and grade 4 IDH-wt glioblastomas) from the CGGA dataset were enriched in pathways related to olfaction, glucoronidation, ascorbate and aldarate metabolism and xenobiotics (Supplementary Fig. 5c) in comparison to the main adult glioma cluster. Here, IDH1 is linked to glioma.