ETV6 and acute myeloid leukemia: Surprisingly, decreased ETV6 expression also was observed in TP53-mutated myeloid malignancies without 12p structural rearrangements (adjusted p-value=0.021, Figure 5C), and was confirmed in an extension cohort of mRNA data from the TCGA[12] (p-value < 0.02 and 0.002 compared to CBF and NK AML cases, respectively; Figure 5D), suggesting an epigenetic mechanism that reduces expression of this gene.