Prior studies have shown that NF1 mutations are present in 7% of all AML cases[40] and further enriched in complex karyotype AML, ranging from 9–19% using gene panel sequencing[41,42] to 22.7% using a SNP-array based method, with approximately one-third of these cases carrying multi-hit deletions[43]. Here, NF1 is linked to acute myeloid leukemia.