An analysis of telomere variant repeats (TVR) in singleton context (i.e., variant hexamers flanked by at least 3 t-type hexamers to each side) showed that telomeric repeats containing TTTGGG hexamers were significantly increased in TP53-mutated AML/MDS compared to the CBF subset (p=1.4×10−7; Figure 6C). The gene discussed is TP53; the disease is acute myeloid leukemia.