Multi-hit mutations in TP53 are reported to occur in 76% (N=174/230) of cases with any TP53 mutation in AML/MDS-EB[5] and 63% (N=253/402) in MDS[4], and supplemental approaches were necessary to clarify multi-hit status by LOH mapping in both studies. This evidence concerns the gene TP53 and acute myeloid leukemia.