TP53 and acute myeloid leukemia: In TP53-mutated AML/MDS, chromothripsis events occurred most frequently on chr5 (7/43 chromothripsis events), chr17 (5/43 chromothripsis events), and chr21 (4/43 chromothripsis events), a pattern distinct from that observed across 623 TP53-mutated samples from the PCAWG consortium[7], in which 408 high confidence chromothripsis regions were reported in 246 samples (38.2%; Figure 4F) We note that the seven samples with chromothripsis within chr5 were a subset of the 33 samples with 5q loss, and do not represent biallelic loss of 5q.