In contrast, non-complex karyotype AML/MDS has a much lower incidence of somatic mutation of ETV6. Structural variants in ETV6 as identified by cytogenetics and interphase FISH have been reported in 1.1% of 3,798 AML cases and 0.2% of 3,375 MDS cases[45]; similarly, somatic SNVs/indels were reported in 1.4% of AMLs and 3.0% of MDS cases among a cohort of 970 patients[46]. Here, ETV6 is linked to acute myeloid leukemia.