Dock7 has been mainly studied in brain development where it regulates neuronal polarity and Schwann cell migration78, 79 and initial studies suggested a similar classical role for Dock7 as a GEF for Cdc42/Rac in cancer.80–82 However, we find that the Dock7 GEF activity is dispensable for the Dock7-mediated activation of AKT and mTOR/S6K. The gene discussed is RPS6KB1; the disease is cancer.