MTOR and cancer: As our understanding of mTOR signaling has grown over recent years, new and alternative mTOR complexes in addition to mTORC1 and mTORC2 have been identified.67–69 Here, we describe an unconventional mTOR complex that plays an important role in the ability of cancer cells to survive when encountering stressful conditions including serum deprivation and the loss of a substratum.