PLA analyses suggest that two of the functionally important binding partners of Dock7, Cdc42 and p-AKT, have an increased capability for associating with Dock7 in cancer cells upon the serum withdrawal (Figures 6A and 3C, respectively), while pan-AKT–Dock7 interactions do not appear to be affected by the presence or absence of serum (Figure 3B). Here, CDC42 is linked to cancer.