Like the Apcloxp/loxp: Lgr5-EGFP-IRES-CreERT2 mouse model, refeeding augmented small intestinal and colonic tumour formation (Fig. 5g, Extended Data Fig. 5f), highlighting that post-fast refeeding enhances intestinal tumourigenicity, including those derived from Lgr5+ ISCs. This evidence concerns the gene LGR5 and colonic neoplasm.