To inhibit polyamine production, we administered the ODC inhibitor DFMO to AL or refed Apcloxp/loxp: Villin-CreERT2 mice (Fig. 6c) and found that ODC inhibition attenuated tumour formation in the refed intestine and colon with no effect on the AL cohort (Fig. 6d, Extended Data Fig. 6f). This evidence concerns the gene ODC1 and neoplasm.