The increase in TMEM106B levels with age was specific to carriers of the rs1990622-A allele in the <i>TMEM106B</i> gene that is associated with increased risk for frontotemporal dementia, Alzheimer's disease, Parkinson's disease, and hippocampal sclerosis with ageing. This evidence concerns the gene TMEM106B and early-onset autosomal dominant Alzheimer disease.