Similarly, in AFD, we and others previously showed that the temperature-dependent expression changes of a subset of genes are regulated by calcium influx via the TAX-2/TAX-4 cGMP-gated channels and the CMK-1 calcium/calmodulin-dependent protein kinase 1 (Figure 4A) (Satterlee et al., 2004; Yu et al., 2014; Kobayashi et al., 2016; Servello et al., 2022). The gene discussed is CAMKK1; the disease is Nager acrofacial dysostosis.