Moreover, while neuropeptide and guanylyl cyclase gene classes, including the previously characterized AFD-specific temperature-regulated gcy-18 thermoreceptor molecule (Yu et al., 2014; Takeishi et al., 2016; Inada et al., 2006), were among genes differentially expressed in AFD (Figure S1B,C), no neuronal gene class was enriched among differentially expressed genes in whole animal samples (Figure S1C). The gene discussed is NPS; the disease is Nager acrofacial dysostosis.