The C. elegans CREB ortholog CRH-1 is expressed in AFD and has previously been implicated in regulating thermosensory behaviors and temperature- and AFD-dependent developmental pathways (Nishida et al., 2011; Nakano et al., 2022; Chen et al., 2016; Park et al., 2021). The gene discussed is CREB1; the disease is Nager acrofacial dysostosis.