LGR5 and adenoma: To this aim, we bred mice carrying Lox-alleles at the tumor suppressors and oncogenes most frequently mutated along the adenoma-to-carcinoma sequence, namely Apc15, Kras16, and Tp5317, each combined with a Cre specific for Lgr5+ ISCs (Lgr5CreERT2-EGFP)18 or for Paneth cells (Lyz1CreERT2)19.