LGR5 and inflammatory bowel disease: We then compared the differentially expressed genes from PC- versus Lgr5-derived mouse tumors and human IBD-CRC versus sCRC (Paneth/IBD-CRC, N = 49 genes, Lgr5/sCRC: N = 27 genes) and visualized their expression across different cell types based on a large scRNAseq CRC study33 (Fig. 3h).