LGR5 and inflammatory bowel disease: Evaluation of the hallmarks from the molecular signature database32 revealed gene sets common to PC-derived tumors and IBD-related CRCs (Interferon α/γ, inflammatory response, Il6/Il2 signaling, Kras, Complement, Allograft rejection), and to Lgr5-derived tumors and sporadic CRCs (Myc targets, G2m Checkpoint, E2F targets and Wnt β-catenin signaling)(Fig. 3g, Suppl.