The opposite was observed for Dclk1 (doublecortin like kinase 1), a Tuft20 and tumor stem cell marker21,22, that was more frequently detected among PC-derived adenomas (Lyz1/Apc: 54.1 % ± 10.5) when compared with Lgr5-derived tumors (Lgr5/Apc: 15.6 % ± 15.7) (Fig. 1g). This evidence concerns the gene APC and adenoma.