LGR5 and neoplasm: Of note, while cells expressing the PC marker lysozyme (Lyz1) were notable in Lgr5-derived tumors (Lgr5/Apc: 30.0 % ± 18.5 positive tumor cells), they were nearly absent in adenomas that originated from Paneth cell mutation (Lyz1/Apc: 0.48 % ± 1.16)(Fig. 1f).