These include oncogenic fusion of the BAF subunit SS18 with an SSX protein in synovial sarcoma and interaction of BAF with EWS-FLI1 in Ewing sarcoma causing aberrant BAF complex targeting74,75, subunit overexpression76, and heterozygous missense mutations within the Brg1 subunit gene in diverse cancers, several of which were characterized as gain-of-function for remodeling activity77. The gene discussed is SMARCA4; the disease is Ewing sarcoma.