Several factors were found to be associated with the increased short-term mortality, including age (5), sex (5), stroke severity and subtype (5), smoking (5), atrial fibrillation (5), serum calcium (10), serum troponin (11), Chronic Kidney Disease (12–15), hypertension (15), the National Institute of Health Stroke Scale (NIHSS) (15, 16), neutrophil-to-lymphocyte ratio (17), low triiodothyronine (T3) (18), hyperglycemia (19, 20), plasma brain natriuretic peptide (21), non-alcoholic fatty liver disease (NAFLD) (22), and elevated blood urea nitrogen (BUN)-to-creatinine ratio (23). The gene discussed is NPPB; the disease is stroke disorder.