Grey matter atrophy has been reported in cognitively healthy individuals positive for amyloid pathology (Fagan et al., 2009; Mormino et al., 2009; Villeneuve et al., 2014) and tau pathology (Wang et al., 2016; Scott et al., 2020; Xie et al., 2020), family history of dementia (Honea et al., 2010, 2011; Mosconi et al., 2014), and the APOE e4 allele (O’Dwyer et al., 2012; Haller et al., 2017; Veldsman et al., 2021). This evidence concerns the gene MAPT and dementia.