APOE and Alzheimer disease: White matter integrity declines have been found in several major white matter tracts including the corpus callosum, cingulum, SLF, IFOF, ILF, and uncinate fasciculus (UF) in cognitively healthy adults who are APOE e4 carriers and have a parental family history of AD (Bendlin et al., 2010; Gold et al., 2012; Westlye et al., 2012; Adluru et al., 2014).