In vitro and in vivo studies have shown that IL-4 can encourage the phagocytosis of microglia/macrophages by activating STAT6 and IL-1 receptor-like 1 signaling (ST2) pathway, and enhance the phagocytosis of hematoma of M2a microglia/macrophages, and IL-4 may have a promising role in hematoma clearance in cerebral hemorrhage (Xu et al., 2020). The gene discussed is STAT6; the disease is hematoma.