For example, CCR1 expressed by microglia after brain hemorrhage can be activated through the CCR1/tetratricopeptide repeat 1 (TPR1)/extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway, thereby promoting the development of neuroinflammation (Yan et al., 2020). Here, MAPK3 is linked to intracranial hemorrhage.