However, arterial injury-induced neointima formation and diet-induced atherosclerosis differ in pathological and mechanistic as well as genetic factors (Ding et al., 2021), knockout of Oct4 significantly impairs perivascular cell migration and promotes Vascular leakage, which in turn inhibits angiogenesis (Hess et al., 2019). The gene discussed is POU5F1; the disease is atherosclerosis.