RUNX3 and severe acute respiratory syndrome: As expected, among the top 10 Reactome pathway: chromatin organization, chromatin modifying enzymes, regulation of TP53 activity, transcriptional regulation by TP53, potential therapeutics for SARS, RUNX3 regulates p14-ARF, positive epigenetic regulation of rRNA expression, gene expression, epigenetic regulation of gene expression, and SUMO E3 ligases SUMOylate target proteins were significantly associated with the tumorigenesis.