CD8A and cancer: BRD4 was significantly correlated with abundance of activated CD8 T-cell (Act_CD8; rho = −0.445, p < 0.001), and effector memeory CD4 T-cell (Tem_CD4; rho = −0.496, p < 0.001) of TILs across human heterogeneous cancers (Figures 5D,E).