There were 18 leading Edge Num in the Glioma pathway, such as AKT1, ARAF, CALM1,CCND1,E2F3,IGF1R, MAP2K2, MAPK1, PIK3CA,PIK3R1,PIK3R2,PLCG1,PRKCA,RAF1,SHC2,SHC3, SOS2 and TP53 (Figure 10F). Here, PLCG1 is linked to central nervous system cancer.