As expected, among the top 10 Reactome pathway: chromatin organization, chromatin modifying enzymes, regulation of TP53 activity, transcriptional regulation by TP53, potential therapeutics for SARS, RUNX3 regulates p14-ARF, positive epigenetic regulation of rRNA expression, gene expression, epigenetic regulation of gene expression, and SUMO E3 ligases SUMOylate target proteins were significantly associated with the tumorigenesis. The gene discussed is TP53; the disease is severe acute respiratory syndrome.