There were 18 leading Edge Num in the Glioma pathway, such as AKT1, ARAF, CALM1,CCND1,E2F3,IGF1R, MAP2K2, MAPK1, PIK3CA,PIK3R1,PIK3R2,PLCG1,PRKCA,RAF1,SHC2,SHC3, SOS2 and TP53 (Figure 10F). This evidence concerns the gene TP53 and glioma.