AR and neoplasm: Five different molecular phenotypes have been reported: 1) AR high CRPC (ARPC); 2) AR low CRPC (ARLPC); 3) amphicrine PC (AMPC) that comprises of tumor cells co-expressing AR and NE gene programs; 4) SCNC that comprises of tumor cells expressing NE genes and negative for AR expression; 5) double negative PCa (DNPC) that is AR and NE double null (Labrecque et al., 2019).