As a result of NED, PCa cells show decreased expression of AR and increased expression of neuroendocrine (NE) lineage markers including enolase 2 (ENO2), chromogranin A (CHGA) and synaptophysin (SYP) (Aggarwal et al., 2014; Aggarwal and Small, 2014). Here, ENO2 is linked to posterior cortical atrophy.